Literature summary for 3.4.14.4 extracted from

Tomic, A.; Tomic, S.
Hunting the human DPP III active conformation: combined thermodynamic and QM/MM calculations (2014), Dalton Trans., 43, 15503-15514.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	QM/MM calculations reveal that the 5-coordinated metal ion is more favourable than the 6-coordinated one in only the most compact DPP III form. In this structure E451 is H-bonded to the metal ion coordinating water. Constraints for the broad substrate specificity of DPP III are the possibility of the substrate adopting the beta-strand shape and its charged N-terminus. The active conformation of the enzyme is the most compact form	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NY33	-	-

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Release 2023.1 (January 2023)