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Literature summary for 3.4.14.2 extracted from

  • McDonald, J.K.; Leibach, F.H.; Grindeland, R.E.; Ellis, S.
    Purification of dipeptidyl aminopeptidase II (dipeptidyl arylamidase II) of the anterior pituitary gland (1968), J. Biol. Chem., 243, 4143-4150.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(D-Ala)3 5 mM, 30% inhibition of hydrolysis of (L-Ala)3, noncompetitive Bos taurus
puromycin
-
Bos taurus
Tris
-
Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
130000
-
gel filtration Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
hypophysis
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(Ala)3 + H2O L-Ala3 Bos taurus ?
-
?
Ala-Ala-2-naphthylamide + H2O
-
Bos taurus Ala-Ala + 2-naphthylamine
-
?
Arg-Ala-2-naphthylamide + H2O
-
Bos taurus Arg-Ala + 2-naphthylamine
-
?
Leu-Ala-2-naphthylamide + H2O
-
Bos taurus Leu-Ala + 2-naphthylamine
-
?
Lys-Ala-2-naphthylamide + H2O
-
Bos taurus Lys-Ala + 2-naphthylamine
-
?
Lys-Ala-OCH3 + H2O
-
Bos taurus ?
-
?
Met-Met-Ala + H2O
-
Bos taurus Met-Met + Ala
-
?
Met-Met-Met + H2O
-
Bos taurus Met-Met + Met
-
?
additional information no hydrolysis occurs if either the carboxyl group or the amino group of otherwise susceptible tripeptides is blocked. Tetrapeptides, tripeptide esters and dipeptides are not attacked Bos taurus ?
-
?
Ser-Met-Gln + H2O
-
Bos taurus Ser-Met + Gln
-
?
Ser-Met-Glu + H2O
-
Bos taurus Ser-Met + Glu
-
?
Ser-Met-OCH3 + H2O
-
Bos taurus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
hydrolysis of tripeptides Bos taurus
5.5
-
hydrolysis of dipeptide arylamides or dipeptide esters Bos taurus