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Literature summary for 3.4.14.2 extracted from
- Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery (2007), Curr. Top. Med. Chem., 7, 621-635.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (3S)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine | - |
Homo sapiens |  |
| (3S)-N1-(4-chlorobenzyl)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine | UAMC00039, potent and specific inhibitor | Homo sapiens | |
| 1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)piperidin-4-amine | - |
Homo sapiens | |
| 1-benzyl-N-(2-oxo-2-piperidin-1-ylethyl)piperidin-4-amine | - |
Homo sapiens | |
| N2-cyclopentyl-N-[(diphenoxyphosphoryl)(phenyl)methyl]glycinamide | - |
Homo sapiens | |
| [(1R)-1-[[(2S)-2,4-diaminobutanoyl]amino]pentyl]boronic acid | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.019 | - |
Lys-Pro-p-nitroanilide | - |
Homo sapiens | |
| 0.041 | - |
Ala-Pro-p-nitroanilide | - |
Homo sapiens | |
| 0.227 | - |
Gly-Pro-p-nitroanilide | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58000 | - |
2 * 58000, SDS-PAGE | Homo sapiens |
| 116000 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Ala-Pro + p-nitroaniline | - |
? | |
| Gly-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Gly-Pro + p-nitroaniline | - |
? | |
| Lys-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Lys-Pro + p-nitroaniline | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 58000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dipeptidyl peptidase II | strongly prefers proline at P1 followed by norleucine | Homo sapiens |
| DPP II | - |
Homo sapiens |
| DPP7 | - |
Homo sapiens |
| QPP | - |
Homo sapiens |
| quiescent cell proline dipeptidase | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3 | - |
Lys-Pro-p-nitroanilide | - |
Homo sapiens | |
| 67.3 | - |
Gly-Pro-p-nitroanilide | - |
Homo sapiens | |
| 77.7 | - |
Lys-Pro-p-nitroanilide | - |
Homo sapiens | |
| 89 | - |
Ala-Pro-p-nitroanilide | - |
Homo sapiens | |
| 105.4 | - |
Ala-Pro-p-nitroanilide | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00000048 | - |
- |
Homo sapiens | (3S)-N1-(4-chlorobenzyl)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine | |
| 0.00000048 | - |
- |
Homo sapiens | [(1R)-1-[[(2S)-2,4-diaminobutanoyl]amino]pentyl]boronic acid | |
| 0.00013 | - |
- |
Homo sapiens | (3S)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine | |
| 0.00104 | - |
- |
Homo sapiens | 1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)piperidin-4-amine | |
| 0.0031 | - |
- |
Homo sapiens | 1-benzyl-N-(2-oxo-2-piperidin-1-ylethyl)piperidin-4-amine | |
| 0.0038 | - |
- |
Homo sapiens | N2-cyclopentyl-N-[(diphenoxyphosphoryl)(phenyl)methyl]glycinamide | |
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