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Literature summary for 3.4.14.1 extracted from

  • Schneck, J.L.; Villa, J.P.; McDevitt, P.; McQueney, M.S.; Thrall, S.H.; Meek, T.D.
    Chemical mechanism of a cysteine protease, cathepsin C, as revealed by integration of both steady-state and pre-steady-state solvent kinetic isotope effects (2008), Biochemistry, 47, 8697-8710.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in CHO cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.4
-
L-Ser-L-Tyr-7-amido-4-methylcoumarin in D2O, pH 5.6, at 21°C Homo sapiens
17
-
L-Ser-L-Tyr-7-amido-4-methylcoumarin in H2O, pH 5.6, at 21°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
protein A affinity chromatography and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ser-L-Tyr-7-amido-4-methylcoumarin + H2O
-
Homo sapiens L-Ser-L-Tyr + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
cathepsin C
-
Homo sapiens
dipeptidyl peptidase I
-
Homo sapiens