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Literature summary for 3.4.14.1 extracted from

  • Huang, F.L.; Tappel, A.L.
    Properties of cathepsin C from rat liver (1972), Biochim. Biophys. Acta, 268, 527-538.
    View publication on PubMed
Search for more literature for 3.4.14.1

Activating Compound

Activating Compound Comment Organism Structure
beta-mercaptoethylamine SH compound required, efficient activator at 25 mM Rattus norvegicus
Cys L-Cys, SH compound required, efficient activator at 25 mM Rattus norvegicus
dithioerythritol SH compound required, efficient activator at 25 mM Rattus norvegicus
DL-homocysteine SH compound required, efficient activator at 25 mM Rattus norvegicus
GSH SH compound required, efficient activator at 25 mM Rattus norvegicus
mercaptoethanol SH compound required, efficient activator at 25 mM Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5
-
 Val-Leu-NH2
-
 Rattus norvegicus
6
-
 Gly-Tyr-NH2
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Br- absolute requirement for halide ions, 10 mM Cl- or Br- required Rattus norvegicus
Cl- absolute requirement for halide ions, 10 mM Cl- or Br- required Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
91.6
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Arg-NH2 + H2O
-
 Rattus norvegicus Ala-Arg + NH3
-
 ?
Ala-Leu-NH2 + H2O
-
 Rattus norvegicus Ala-Leu + NH3
-
 ?
Ala-Tyr-NH2 + H2O
-
 Rattus norvegicus Ala-Tyr + NH3
-
 ?
Gly-Ala-NH2 + H2O
-
 Rattus norvegicus Gly-Ala + NH3
-
 ?
Gly-Gly-Phe-NH2 + H2O
-
 Rattus norvegicus Gly-Gly + Phe-NH2
-
 ?
Gly-L-Phe-NH2 + H2O
-
 Rattus norvegicus Gly-L-Phe + NH3
-
 ?
Gly-L-Tyr-NH2 + H2O
-
 Rattus norvegicus Gly-L-Tyr + NH3
-
 ?
Gly-Leu-NH2 + H2O
-
 Rattus norvegicus Gly-Leu + NH3
-
 ?
Gly-Tyr-Gly + H2O
-
 Rattus norvegicus Gly-Tyr + Gly
-
 ?
His-Leu-NH2 + H2O
-
 Rattus norvegicus His-Leu + NH3
-
 ?
His-Tyr-NH2 + H2O
-
 Rattus norvegicus His-Tyr + NH3
-
 ?
Ile-Leu-NH2 + H2O
-
 Rattus norvegicus Ile-Leu + NH3
-
 ?
Leu-Tyr-NH2 + H2O
-
 Rattus norvegicus Leu-Tyr + NH3
-
 ?
Lys-Gly-NH2 + H2O
-
 Rattus norvegicus Lys-Gly + NH3
-
 ?
additional information the most favorable substrates are tripeptides or dipeptide amides that have as the NH2-terminal group a small residue and that have the aliphatic residue leucine at the penultimate position Rattus norvegicus ?
-
 ?
Pro-Leu-NH2 + H2O
-
 Rattus norvegicus Pro-Leu + NH3
-
 ?
Pro-Phe-NH2 + H2O
-
 Rattus norvegicus Pro-Phe + NH3
-
 ?
Ser-Leu-NH2 + H2O
-
 Rattus norvegicus Ser-Leu + NH3
-
 ?
Ser-Tyr-NH2 + H2O
-
 Rattus norvegicus Ser + Tyr + NH3
-
 ?
Thr-Leu-NH2 + H2O
-
 Rattus norvegicus Thr-Leu + NH3
-
 ?
Val-Leu-NH2 + H2O
-
 Rattus norvegicus Val-Leu + NH3
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2 7.8
-
 Rattus norvegicus