Literature summary for 3.4.13.9 extracted from

Uramatsu, S.; Liu, G.; Yang, Q.; Uramatsu, M.; Chi, H.; Lu, J.; Yamashita, K.; Kodama, H.
Characterization of prolidase I and II purified from normal human erythrocytes: comparison with prolidase in erythrocytes from a patient with prolidase deficiency (2009), Amino Acids, 37, 543-551.

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Activating Compound

Activating Compound	Comment	Organism	Structure
D,L-ethionine	enhances the activity of isozyme prolidase I, D,L-ethionine strongly enhances the activity of isozyme prolidase II compared with L-ethionine	Homo sapiens
D,L-homocysteine	enhances the activity of isozyme prolidase I at low concentration	Homo sapiens
D,L-homocysteine	weakly enhances the activity of isozyme prolidase II	Homo sapiens
D,L-methionine	slightly enhances the activity of isozyme prolidase I at low concentration	Homo sapiens
D,L-methionine	the activity of isozyme prolidase II against L-Met-L-Pro is enhanced by D,L-methionine	Homo sapiens
D-ethionine	enhances the activity of isozymes prolidase I and II	Homo sapiens
D-methionine	the activity of isozyme prolidase I against Gly-L-Pro is strongly enhanced by D-methionine	Homo sapiens
D-methionine	the activity of isozyme prolidase II against L-Met-L-Pro is enhanced by D-methionine	Homo sapiens
L-ethionine	enhances the activity of isozyme prolidase I	Homo sapiens
L-methionine	slightly enhances the activity of isozyme prolidase I at low concentration	Homo sapiens
L-methionine	the activity of isozyme prolidase II against L-Met-L-Pro is enhanced by L-methionine	Homo sapiens
additional information	N-acetyl-L-methionine has no effect on activity of isozymes prolidase I and prolidase II	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
D,L-homocysteine	inhibits the activity at 50 mM	Homo sapiens
D,L-homocysteine-thiolactone	inhibits the activities of isozymes prolidase I and II in a concentration-dependent manner	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Gly-L-Pro + H2O	-	Homo sapiens	Gly + L-Pro	-	?
L-Met-L-Pro + H2O	-	Homo sapiens	L-Met + L-Pro	-	?

Synonyms

Synonyms	Comment	Organism
prolidase I	isozyme	Homo sapiens
prolidase II	isozyme	Homo sapiens

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Release 2023.1 (January 2023)