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Literature summary for 3.4.13.9 extracted from

  • Surazynski, A.; Sienkiewicz, P.; Wolczynski, S.; Palka, J.
    Differential effects of echistatin and thrombin on collagen production and prolidase activity in human dermal fibroblasts and their possible implication in beta1-integrin-mediated signaling (2005), Pharm. Res., 51, 217-221.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
thrombin treatment of cells results in enhancement of collagen production and enzyme activity and expression, accompanied by raise in expression of focal adhesion kinase pp125 and mitogen-activated protein kinases Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
echistatin treatment of cells results in inhibition of collagen production and enzyme activity and expression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
regulation of enzyme activity and collagen biosynthesis may involve beta1-integrin-dependent signaling
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast derived from skin Homo sapiens
-