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Literature summary for 3.4.13.9 extracted from

  • Chiravuri, M.; Agarraberes, F.; Mathieu, S.L.; Lee, H.; Huber, B.T.
    Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase (2000), J. Immunol., 165, 5695-5702.
    View publication on PubMed
Search for more literature for 3.4.13.9

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination and analysis, expression in human 293T fibroblastic cells as GFP- and Myc-tagged enzymes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic vesicle post-Golgi vesicular fraction Homo sapiens 31410
-
cytosol
-
 Homo sapiens 5829
-
extracellular secretion Homo sapiens
-
-
additional information subscellular localization in cells natively expressing the enzyme and in cells recombinantly expressing the enzyme Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
 x * 58000, processed glycoslyated enzyme, SDS-PAGE, x * 53000, unprocessed enzyme, SDS-PAGE Homo sapiens
58000
-
 x * 58000, processed glycoslyated enzyme, SDS-PAGE, x * 53000, unprocessed enzyme, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein 5 kDa N-linked glycosyl residue, glycosylation is required for activity Homo sapiens
proteolytic modification a 29 amino acid signal or propeptide is cleaved from the enzyme after synthesis Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
from JURKAT cells Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Pro-amino-4-trifluoromethylcoumarin + H2O
-
 Homo sapiens alanine + Pro-4-trifluoromethylcoumarin
-
 ?
additional information the acive enzyme form is N-glycosylated, unglycosylated enzyme is not catalytically active Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 58000, processed glycoslyated enzyme, SDS-PAGE, x * 53000, unprocessed enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
More enzyme belongs to the methionyl amino peptidase family M24, fomerly EC 3.4.3.7 Homo sapiens
post-proline-cleaving aminopeptidase
-
 Homo sapiens
QPP
-
 Homo sapiens
quiescent cell proline dipeptidase
-
 Homo sapiens