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Literature summary for 3.4.13.5 extracted from

  • Yamada, S.; Tanaka, Y.; Sameshima, M.; Furuichi, M.
    Properties of Nalpha-acetylhistidine deacetylase in brain of rainbow trout Oncorhynchus mykiss (1993), Comp. Biochem. Physiol. B, 106, 309-315.
No PubMed abstract available
Search for more literature for 3.4.13.5

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Oncorhynchus mykiss
ATP
-
 Oncorhynchus mykiss
bestatin 0.01 mM, 15% inhibition of the enzyme from eye, 1% inhibition of the enzyme from brain Oncorhynchus mykiss
CoA
-
 Oncorhynchus mykiss
Cu2+
-
 Oncorhynchus mykiss
EDTA
-
 Oncorhynchus mykiss
Hg2+
-
 Oncorhynchus mykiss
Pb2+
-
 Oncorhynchus mykiss
PCMB
-
 Oncorhynchus mykiss

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 2 * 55000, SDS-PAGE Oncorhynchus mykiss
120000
-
 brain and eye enzyme, gel filtration Oncorhynchus mykiss

Organism

Organism UniProt Comment Textmining
Oncorhynchus mykiss
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Oncorhynchus mykiss

Source Tissue

Source Tissue Comment Organism Textmining
brain all regions of the brain except for the spinal cord and the optic nerve Oncorhynchus mykiss
-
eye
-
 Oncorhynchus mykiss
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.03
-
 brain Oncorhynchus mykiss
1.27
-
 eye Oncorhynchus mykiss

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anserine + H2O 16% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss beta-Ala + 1-methylhistidine
-
 ?
carnosine + H2O 83% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss ?
-
 ?
Gly-Gly + H2O 385% of the activity with N-acetyl-L-His Oncorhynchus mykiss Gly + Gly
-
 ?
Gly-L-His + H2O 110% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss Gly + L-His
-
 ?
Gly-L-Leu + H2O 832% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss Gly + L-Leu
-
 ?
homocarnosine + H2O 67% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss ?
-
 ?
L-Ala-L-His + H2O 105% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss L-Ala + L-His
-
 ?
L-Leu-Gly + H2O 101% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss L-Leu + Gly
-
 ?
N-acetyl-L-Glu + H2O 23% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss L-Glu + acetate
-
 ?
N-acetyl-L-His + H2O
-
 Oncorhynchus mykiss His + acetate
-
 ?
N-acetyl-L-Leu + H2O 110% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss L-Leu + acetate
-
 ?
N-acetyl-L-methionine + H2O 254% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss L-Met + acetate
-
 ?
N-acetyl-L-Trp + H2O 30% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss L-Trp + acetate
-
 ?
Nalpha-chloroacetyl-L-Leu + H2O 1235% of the activity with N-acetyl-L-His, brain enzyme Oncorhynchus mykiss L-Leu + chloroacetate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 55000, SDS-PAGE Oncorhynchus mykiss

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
50
-
-
 Oncorhynchus mykiss

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
10 60 10°C: about 50% of maximal activity, brain and eye enzyme, 60°C, about 40% of maximal activity, brain enzyme, 60°C: about 90% of maximal activity, eye enzyme Oncorhynchus mykiss

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 6.5
-
 Oncorhynchus mykiss

pH Range

pH Minimum pH Maximum Comment Organism
5 9 less than 10% of maximal activity at pH 5.0 and 9.0 Oncorhynchus mykiss

pH Stability

pH Stability pH Stability Maximum Comment Organism
5.2 8.1 maximal stability Oncorhynchus mykiss