Literature summary for 3.4.11.9 extracted from

Banu, S.K.; Stanley, J.A.; Sivakumar, K.K.; Arosh, J.A.; Barhoumi, R.; Burghardt, R.C.
Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in CrVI-induced adverse effects on germ cell nest breakdown and follicle development in rats (2015), Biol. Reprod., 92, 67 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
Cr6+	CrVI, a heavy metal endocrine-disrupting chemical industrially widely used, gestational exposure to CrVI increases germ cell/oocyte apoptosis and advance germ cell nest (GCN) breakdown. CrVI increases X-prolyl aminopeptidase (Xpnpep) 2 (a marker for premature ovarian failure in humans) during germ cell nest (GCN) breakdown, it decreases Xpnpep2 during postnatal follicle development, and increases colocalization of Xpnpep2 with collagens Col3 and Col4. Phenotype, overview	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q99MA2	-	-
Rattus norvegicus Sprague Dawley	Q99MA2	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ovary	the enzyme colocalizes with collagens Col3 and Col4 in fetal ovaries around the germ cells, GCN, and along the ovigerous cords	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
X-prolyl aminopeptidase 2	-	Rattus norvegicus
XPNPEP2	-	Rattus norvegicus

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Release 2023.1 (January 2023)