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Literature summary for 3.4.11.9 extracted from

  • Wolfrum, S.; Richardt, G.; Dominiak, P.; Katus, H.A.; Dendorfer, A.
    Apstatin, a selective inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin-dependent pathway (2001), Br. J. Pharmacol., 134, 370-374.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
apstatin selective for aminopeptidase P Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme participates in the myocardial kinin metabolism to the same extent as angiotensin-converting enzyme, APP inhibition leads to a reduction in myocardial infarct size by the bradykinin-dependent pathway, synergistic with inhibition of angiotensin-converting enzyme, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bradykinin + H2O
-
 Rattus norvegicus Arg + des-Arg-bradykinin
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 ?
additional information the enzyme participates in the myocardial kinin metabolism to the same extent as angiotensin-converting enzyme, APP inhibition leads to a reduction in myocardial infarct size by the bradykinin-dependent pathway, synergistic with inhibition of angiotensin-converting enzyme, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase P
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 Rattus norvegicus
APP
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 Rattus norvegicus
More the enzyme belongs to the peptidase family M24 Rattus norvegicus