Activating Compound | Comment | Organism | Structure |
---|---|---|---|
4-chloromercuriphenyl sulfonic acid | inhibits hydrolysis of Gly-Pro-Hyp, activates hydrolysis of bradykinin | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-chloromercuriphenyl sulfonic acid | inhibits hydrolysis of Gly-Pro-Hyp, activates hydrolysis of bradykinin | Sus scrofa | |
bradykinin | hydrolysis of Gly-Pro-Hyp | Sus scrofa | |
cilazaprilat | inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methyl-7-coumarylamide, substance P, and beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin | Sus scrofa | |
enaprilat | inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methylcoumarin 7-amide, substance P, and beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin | Sus scrofa | |
Mn2+ | above, 0.01 mM, hydrolysis of bradykinin and Arg-Pro-Pro | Sus scrofa | |
ramiprilat | inhibits hydrolysis of Gly-Pro-Hyp, Gly-Pro-4-methylcoumarin 7-amide, substance P or beta-casomorphin. Weak inhibition of hydrolysis of Arg-Pro-Pro. No effect on hydrolysis of bradykinin | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.7 | - |
Gly-Pro-Hyp | - |
Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | 4-10 mM, activates hydrolysis of Gly-Pro-Hyp, beta-casomorphin or substance P | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | brush border membrane | Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Arg-Pro-Pro + H2O | - |
Sus scrofa | Arg + Pro-Pro | - |
? | |
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O | - |
Sus scrofa | Arg + Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | - |
? | |
beta-casomorphin + H2O | - |
Sus scrofa | ? | - |
? | |
Gly-Pro-Hyp + H2O | - |
Sus scrofa | Gly + Pro-Hyp | - |
? | |
Substance P + H2O | - |
Sus scrofa | ? | - |
? |