Application | Comment | Organism |
---|---|---|
medicine | the enzyme might be a target in treatment of salt-dependent hypertension with RB150 as an antihypertensive agent | Mus musculus |
medicine | the enzyme might be a target in treatment of salt-dependent hypertension with RB150 as an antihypertensive agent | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EC33 | - |
Mus musculus | |
EC33 | - |
Rattus norvegicus | |
RB150 | selective and specific prodrug of the enzyme inhibitor EC33, inhibits the enzyme given i.v. to mice | Mus musculus | |
RB150 | selective and specific prodrug of the enzyme inhibitor EC33, inhibits the enzyme given i.v. to rats | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview | ? | - |
? | |
additional information | Rattus norvegicus | the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male Swiss mice | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
hypothalamus | - |
Mus musculus | - |
hypothalamus | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
additional information | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview | Mus musculus | ? | - |
? | |
additional information | the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase A | - |
Mus musculus |
aminopeptidase A | - |
Rattus norvegicus |
APA | - |
Mus musculus |
APA | - |
Rattus norvegicus |