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Literature summary for 3.4.11.7 extracted from

  • Fournie-Zaluski, M.C.; Fassot, C.; Valentin, B.; Djordjijevic, D.; Reaux-Le Goazigo, A.; Corvol, P.; Roques, B.P.; Llorens-Cortes, C.
    Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: A potential treatment of salt-dependent hypertension (2004), Proc. Natl. Acad. Sci. USA, 101, 7775-7780.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.11.7

Application

Application Comment Organism
medicine the enzyme might be a target in treatment of salt-dependent hypertension with RB150 as an antihypertensive agent Mus musculus
medicine the enzyme might be a target in treatment of salt-dependent hypertension with RB150 as an antihypertensive agent Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
EC33
-
 Mus musculus
EC33
-
 Rattus norvegicus
RB150 selective and specific prodrug of the enzyme inhibitor EC33, inhibits the enzyme given i.v. to mice Mus musculus
RB150 selective and specific prodrug of the enzyme inhibitor EC33, inhibits the enzyme given i.v. to rats Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview ?
-
 ?
additional information Rattus norvegicus the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male Swiss mice
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Rattus norvegicus
-
hypothalamus
-
 Mus musculus
-
hypothalamus
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Mus musculus
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview Mus musculus ?
-
 ?
additional information the enzyme is involved in conversion of angiotensin II to angiotensin III and thus in controlling of vasopressin release and blood pressure, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase A
-
 Mus musculus
aminopeptidase A
-
 Rattus norvegicus
APA
-
 Mus musculus
APA
-
 Rattus norvegicus