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Literature summary for 3.4.11.7 extracted from

  • Mitsui, T.; Nomura, S.; Itakura, A.; Mizutani, S.
    Role of aminopeptidases in the blood pressure regulation (2004), Biol. Pharm. Bull., 27, 768-771.
    View publication on PubMed
Search for more literature for 3.4.11.7

Inhibitors

Inhibitors Comment Organism Structure
amastatin an APA inhibitor, enzyme inhibition leads to increased blood pressure Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin II + H2O Rattus norvegicus angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure Asp + angiotensin III
-
 ?
additional information Rattus norvegicus administration of purified enzyme into hypertensive rats leads to a decrease in blood pressure, while enzyme inhibition increases blood pressure ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure Rattus norvegicus Asp + angiotensin III
-
 ?
angiotensin II + H2O i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus Asp + angiotensin III i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe ?
additional information administration of purified enzyme into hypertensive rats leads to a decrease in blood pressure, while enzyme inhibition increases blood pressure Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
aminopeptidase A
-
 Rattus norvegicus
APA
-
 Rattus norvegicus