Literature summary for 3.4.11.6 extracted from

Saitoh, Y.; Koizumi, K.; Minami, T.; Sekine, K.; Sakurai, H.; Saiki, I.
A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells (2006), Biol. Pharm. Bull., 29, 709-712.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-methyl cyclohexan bestatin	i.e. BE15, strong inhibition	Homo sapiens
bestatin	-	Homo sapiens
methyl bestatin	-	Homo sapiens
additional information	inhibitory potency of bestatin and derivatives on enzyme activity, umbilical vein endothelial cell vessel formation, and cell invasion and migration, overview	Homo sapiens
tert-butyl bestatin	i.e. BE17, the BE15 derivative has a dual inhibitory effect of invasion and motility on tumor and endothelial cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-375 cell	-	Homo sapiens	-
human umbilical vein endothelial cell	i.e. HUVEC	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Ala-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	L-Ala + 7-amino-4-methylcoumarin	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	in vivo assay at	Homo sapiens

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Release 2023.1 (January 2023)