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Literature summary for 3.4.11.6 extracted from

  • Tanioka, T.; Hattori, A.; Masuda, S.; Nomura, Y.; Nakayama, H.; Mizutani, S.; Tsujimoto, M.
    Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases (2003), J. Biol. Chem., 278, 32275-32283.
    View publication on PubMed
Search for more literature for 3.4.11.6

Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa S3 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline effective Homo sapiens
amastatin
-
 Homo sapiens
bestatin
-
 Homo sapiens
additional information EDTA has no effect up to 1 mM Homo sapiens
puromycin weak Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00318
-
 Arg-4-methylcoumaryl-7-amide pH 7.5, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum lumenal side Homo sapiens 5783
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc essential zinc-binding site HEXXH at amino acid residues 370-374 with a second glutamic acid separated by 18 amino acids Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is induced by interferon-gamma, the enzyme can trim the N-terminal extended precursor to antigenic peptides in the endoplasmic reticulum ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6P179
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein contains high mannose-type sugar chains Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Arg-4-methylcoumaryl-7-amide + H2O
-
 Homo sapiens Arg + 7-amino-4-methylcoumarin
-
 ?
additional information the enzyme is induced by interferon-gamma, the enzyme can trim the N-terminal extended precursor to antigenic peptides in the endoplasmic reticulum Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
L-RAP
-
 Homo sapiens
leukocyte-derived arginine aminopeptidase
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3
-
 Arg-4-methylcoumaryl-7-amide pH 7.5, 37°C Homo sapiens