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Literature summary for 3.4.11.3 extracted from
- A specific dileucine motif is required for the GGA-dependent entry of newly synthesized insulin-responsive aminopeptidase into the insulin-responsive compartment (2006), J. Biol. Chem., 281, 33457-33466.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in 3T3-L1 cell | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| L53A/L54A | no change in intracellular trafficking | Mus musculus |
| L76A/L77A | mutation results in rapid default of the enzyme to the cell surface. In presence of a dominant interfering mutant of clathrin adaptor GGA1, insulin-stimulated translocation of wild-type enzyme, but not of mutant L76A/L77A is inhibited | Mus musculus |
| additional information | alanine-substitution of 9 residues amino- or carboxy-terminal to the dileucine motif at positions 76, 77 does not perturb basal intracellular sequestration of the enzyme | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
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Release 2023.1 (January 2023)
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