Any feedback?
Literature summary for 3.4.11.3 extracted from
- Insulin-regulated aminopeptidase (2004), Proteases in Biology and Disease (Hooper, N. M. ; Lendeckel, U. , eds. ) Springer, 2, 61-81.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic vesicle | GLUT4-containing. Insulin-regulated aminopeptidase is a marker protein for specialized vesicles containing the insulin-responsive glucose transporter, GLUT4. The enzyme is thought to be involved in the tethering of GLUT4 vesicles to intracellular compartments | Homo sapiens | 31410 | - |
| cytosol | P-LAP is translocated from the cytosol to the plasma membrane by oxytocin stimulation in vascular endothelial cells and by vasopressin in renal cells | Homo sapiens | 5829 | - |
| membrane | the soluble form present in maternal serum is converted from the membrane-bound form in placenta by an enzyme with metalloprotease activity by posttranslational proteolytic cleavage between Phe154 and Ala155. P-LAP is translocated from the cytosol to the plasma membrane by oxytocin stimulation in vascular endothelial cells and by vasopressin in renal cells | Homo sapiens | 16020 | - |
| plasma membrane | translocated with GLUT4 to the plasma membrane unedr insulin stimulation | Homo sapiens | 5886 | - |
| soluble | the soluble form present in maternal serum is converted from the membrane-bound form in placenta by an enzyme with metalloprotease activity | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| oxytocin + H2O | Homo sapiens | in the placenta the enzyme is thought to play a role in the prevention of premature labour and maintenance of an adequate blood flow to the uterus | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | the soluble form present in maternal serum is converted from the membrane-bound form in placenta by an enzyme with metalloprotease activity by posttranslational proteolytic cleavage between Phe154 and Ala155 | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | membrane | Bos taurus | - |
| brain | - |
Mus musculus | - |
| epididymis | - |
Rattus norvegicus | - |
| fat pad | - |
Rattus norvegicus | - |
| placenta | expressed in differentiated trophoblasts | Homo sapiens | - |
| placenta | in the placenta the enzyme is thought to play a role in the prevention of premature labour and maintenance of an adequate blood flow to the uterus | Homo sapiens | - |
| trophoblast | differentiated | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin III + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | involvement of the enzyme in memory processing. AT4 ligands, upon binding to the catalytic site of insulin-regulated aminopeptidase, enhance spatial learning, facilitate memory retention and retrieval and reverse amnesia | Homo sapiens | ? | - |
? | |
| oxytocin + H2O | in the placenta the enzyme is thought to play a role in the prevention of premature labour and maintenance of an adequate blood flow to the uterus | Homo sapiens | ? | - |
? | |
| oxytocin + H2O | cleavage sites: Cys-/-Tyr-/-Ile-/-Gln-/-Asn-/-Cys-Pro-Leu-Gly-NH2 | Homo sapiens | ? | - |
? | |
| oxytocin + H2O | cleavage sites: Cys-/-Tyr-/-Phe-/-Gln-Asn-Cys-Pro-Arg-Gly-NH2 | Homo sapiens | ? | - |
? | |
| oxytocin + H2O | enzyme opens the N-terminal cystine loop of oxytocin | Homo sapiens | ? | - |
? | |
| somatostatin + H2O | - |
Mus musculus | ? | - |
? | |
| Vasopressin + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AT4 receptor | - |
Mus musculus |
| AT4 receptor | - |
Homo sapiens |
| AT4 receptor | - |
Rattus norvegicus |
| AT4 receptor | - |
Bos taurus |
| cystine aminopeptidase | - |
Homo sapiens |
| insulin-regulated aminopeptidase | - |
Mus musculus |
| insulin-regulated aminopeptidase | - |
Homo sapiens |
| insulin-regulated aminopeptidase | - |
Rattus norvegicus |
| insulin-regulated aminopeptidase | - |
Bos taurus |
| IRAP | - |
Mus musculus |
| IRAP | - |
Homo sapiens |
| IRAP | - |
Rattus norvegicus |
| IRAP | - |
Bos taurus |
| oxytocinase | - |
Mus musculus |
| oxytocinase | - |
Homo sapiens |
| oxytocinase | - |
Rattus norvegicus |
| oxytocinase | - |
Bos taurus |
| P-LAP | - |
Homo sapiens |
| Placental leucine aminopeptidase | - |
Mus musculus |
| Placental leucine aminopeptidase | - |
Homo sapiens |
| Placental leucine aminopeptidase | - |
Rattus norvegicus |
| Placental leucine aminopeptidase | - |
Bos taurus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
