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Literature summary for 3.4.11.3 extracted from

  • Demaegdt, H.; Laeremans, H.; De Backer, J.P.; Mosselmans, S.; Le, M.T.; Kersemans, V.; Michotte, Y.; Vauquelin, G.; Vanderheyden, P.M.
    Synergistic modulation of cystinyl aminopeptidase by divalent cation chelators (2004), Biochem. Pharmacol., 68, 893-900.
    View publication on PubMed
Search for more literature for 3.4.11.3

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline IC50: 0.2 mM. Inhibitory effect is substantially potentiated by both EDTA and EGTA. A combined and complete inhibition of the enzyme activity by 0.1 mM EDTA and 0.1 mM 1,10-phenanthroline can be prevented in the presence of 0.04-0.1 mM ZnCl2 Cricetulus griseus
angiotensin IV IC50: 0.00072 mM Cricetulus griseus
EDTA weak Cricetulus griseus
EGTA weak Cricetulus griseus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Cricetulus griseus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ complete inhibition of the enzyme activity by 0.1 mM EDTA and 0.1 mM 1,10-phenanthroline can be prevented in the presence of 0.04-0.1 mM ZnCl2 Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO-K1 cell
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-leucine-p-nitroanilide + H2O
-
 Cricetulus griseus L-leucine + p-nitroaniline
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00072
-
 IC50: 0.00072 mM Cricetulus griseus angiotensin IV
0.2
-
 IC50: 0.2 mM. Inhibitory effect is substantially potentiated by both EDTA and EGTA. A combined and complete inhibition of the enzyme activity by 0.1 mM EDTA and 0.1 mM 1,10-phenanthroline can be prevented in the presence of 0.04-0.1 mM ZnCl2 Cricetulus griseus 1,10-phenanthroline