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Literature summary for 3.4.11.3 extracted from

  • Itoh, C.; Nagamatsu, A.
    An aminopeptidase activity from porcine kidney that hydrolyzes oxytocin and vasopressin: purification and partial characterization (1995), Biochim. Biophys. Acta, 1243, 203-208.
    View publication on PubMed
Search for more literature for 3.4.11.3

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol stimulates at 1 mM Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Sus scrofa
2-mercaptoethanol inhibition above 1 mM Sus scrofa
amastatin
-
 Sus scrofa
bestatin
-
 Sus scrofa
cysteine
-
 Sus scrofa
EDTA slightly Sus scrofa
Ni2+
-
 Sus scrofa
p-chloromercuribenzoate
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.11
-
 S-benzyl-L-cysteine-p-nitroanilide
-
 Sus scrofa
0.15
-
 L-Leu-4-nitroanilide
-
 Sus scrofa
0.43
-
 L-Lysine-p-nitroanilide
-
 Sus scrofa
0.83
-
 L-methionine-p-nitroanilide
-
 Sus scrofa
1.43
-
 L-alanine-p-nitroanilide
-
 Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ stimulates Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
104000
-
 1 * 104000, SDS-PAGE Sus scrofa
105000
-
 gel filtration Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine-p-nitroanilide + H2O
-
 Sus scrofa L-alanine + p-nitroaniline
-
 ?
L-Leu-4-nitroanilide + H2O
-
 Sus scrofa L-Leu + 4-nitroaniline
-
 ?
L-lysine-p-nitroanilide + H2O
-
 Sus scrofa L-lysine + p-nitroaniline
-
 ?
L-methionine-p-nitroanilide + H2O
-
 Sus scrofa L-methionine + p-nitroaniline
-
 ?
S-benzyl-L-cysteine-p-nitroanilide + H2O
-
 Sus scrofa S-benzyl-L-cysteine + p-nitroaniline
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 104000, SDS-PAGE Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
-
 Sus scrofa