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Literature summary for 3.4.11.3 extracted from

  • Yamamoto, M.; Ishiura, S.; Sugita, H.
    Chloride-activated cystine aminopeptidase: A new enzyme in human skeletal muscle (1988), Biomed. Res., 9, 11-19.
No PubMed abstract available
Search for more literature for 3.4.11.3

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol slight Homo sapiens
bestatin
-
 Homo sapiens
EDTA not Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.006
-
 S-benzyl-cysteine-4-methylcoumarin 7-amide
-
 Homo sapiens
0.022
-
 arginine-4-methylcoumarin 7-amide
-
 Homo sapiens
0.11
-
 L-Phe-7-amido-4-methylcoumarin
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cl- stimulation Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
66000
-
 gel filtration, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Phe-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens L-Phe + 7-amino-4-methylcoumarin
-
 ?
additional information broad specificity Homo sapiens ?
-
 ?
S-benzyl-cysteine-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens S-benzyl-cysteine + 7-amino-4-methylcoumarin
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7 8 pH 7.0: about 15% of activity maximum, pH 8.0: about 10% of activity maximum Homo sapiens