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Literature summary for 3.4.11.3 extracted from
- Oxytocinase (L-cystine aminopeptidase) from term human placenta (1980), Biochem. Int., 1, 10-18.
No PubMed abstract available
General Stability
| General Stability | Organism |
|---|---|
| freeze-thawing, stable | Homo sapiens |
| lyophilization, stable | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Homo sapiens |  |
| Cd2+ | - |
Homo sapiens | |
| Cu2+ | - |
Homo sapiens | |
| NaCN | - |
Homo sapiens | |
| Pb2+ | inhibits at pH 6.0, not at pH 7.4 | Homo sapiens | |
| Zn2+ | inhibition at pH 6.0 not at pH 7.5 | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.29 | - |
S-benzyl-L-cysteine-p-nitroanilide | pH 6.0 | Homo sapiens | |
| 0.36 | - |
leucyl-p-nitroanilide | pH 7.4 | Homo sapiens | |
| 0.45 | - |
S-benzyl-L-cysteine-p-nitroanilide | pH 7.4 | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 24000 | - |
isoenzyme I, x * 24000, SDS-PAGE | Homo sapiens |
| 30000 | - |
x * 30000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
2 forms: I, II | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | - |
Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 52 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -15°C, 0.01 M potassium phosphate, pH 7.4, protein concentration 0.5 mg/ml, 6 months | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | glycyl-p-nitroanilide | Homo sapiens | ? | - |
? | |
| oxytocin + H2O | - |
Homo sapiens | acyclic peptide + H2O | - |
? | |
| S-benzyl-L-cysteine-p-nitroanilide + H2O | - |
Homo sapiens | S-benzyl-L-cysteine + p-nitroaniline | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 30000, SDS-PAGE | Homo sapiens |
| ? | isoenzyme I, x * 24000, SDS-PAGE | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
form I | Homo sapiens |
| 7.4 | - |
form II | Homo sapiens |
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Release 2023.1 (January 2023)
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