Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Tyr-Ser-Pro-Nfs1 + H2O | Saccharomyces cerevisiae | the enzyme is involved in the processing pathway of yeast Nfs1 during its translocation into the mitochondrial matrix. Nfs1 from Saccharomyces cerevisiae undergoes two steps of proteolytic processing: first the mitochondrial processing peptidase (MPP) cleaves the precursor between Phe33 and Tyr34. Then Icp55 cleaves between Pro36 and Pro37 removing three amino acids residues (Tyr-Ser-Pro) | Nfs1 + Tyr-Ser-Pro | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | P40051 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Tyr-Ser-Pro-Nfs1 + H2O | the enzyme is involved in the processing pathway of yeast Nfs1 during its translocation into the mitochondrial matrix. Nfs1 from Saccharomyces cerevisiae undergoes two steps of proteolytic processing: first the mitochondrial processing peptidase (MPP) cleaves the precursor between Phe33 and Tyr34. Then Icp55 cleaves between Pro36 and Pro37 removing three amino acids residues (Tyr-Ser-Pro) | Saccharomyces cerevisiae | Nfs1 + Tyr-Ser-Pro | - |
? | |
Tyr-Ser-Pro-Nfs1 + H2O | the enzyme is involved in the processing pathway of yeast Nfs1 during its translocation into the mitochondrial matrix. Nfs1 from Saccharomyces cerevisiae undergoes two steps of proteolytic processing: first the mitochondrial processing peptidase (MPP) cleaves the precursor between Phe33 and Tyr34. Then Icp55 cleaves between Pro36 and Pro37 removing three amino acids residues (Tyr-Ser-Pro). In the absence of Nfs1 processing by mitochondrial processing peptidase (MPP), the Nfs1 precursor is not cleaved by Icp55. The two prolines are of importance for the Icp55 cleavage reaction, because the replacement of a single proline changes the specificity to a new cleavage site without eliminating the cleavage reaction per se | Saccharomyces cerevisiae | Nfs1 + Tyr-Ser-Pro | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Icp55 | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
malfunction | Nfs1 purified from the knockout strain, DELTAip55, detected three additional amino acids (Tyr-Ser-Pro), at the N-terminus of Nfs1 | Saccharomyces cerevisiae |