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Literature summary for 3.4.11.26 extracted from
- Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability (2009), Cell, 139, 428-439.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | Icp55 behaves like a protein that is peripherally attached to the mitochondrial inner membrane from the matrix side | Saccharomyces cerevisiae | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
- |
Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | Icp55 is critical for stabilization of the mitochondrial proteome. Icp55 removes an amino acid from a characteristic set of N-termini of preprotein intermediates generated by mitochondrial processing peptidase. Thereby Icp55 converts instable intermediates into stable proteins | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | P40051 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Icp55 is critical for stabilization of the mitochondrial proteome. Icp55 removes an amino acid from a characteristic set of N-termini of preprotein intermediates generated by mitochondrial processing peptidase. Thereby Icp55 converts instable intermediates into stable proteins | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | global analysis of the N-proteome of yeast mitochondria, revealing the N-termini of 615 different proteins. The N-proteome of icp55DELTA mitochondria yielded proteins whose N-terminus differs by one residue from the mature N-terminus of wild-type mitochondria. Icp55 cleaves between the last amino acid of the presequence (tyrosine, leucine or phenylalanine) and the first residue of the mature protein, preferentially serine, alanine and threonine. The most frequent residue tyrosine is efficiently removed by Icp55 and thus is the best substrate of Icp55. The efficiency of cleavage is lower for leucine and phenylalanine | Saccharomyces cerevisiae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Icp55 | - |
Saccharomyces cerevisiae |
| YER078c | - |
Saccharomyces cerevisiae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | icp55DELTA cells are defective in growth on nonfermentable medium at elevated temperature (37°C) | Saccharomyces cerevisiae |
| physiological function | Icp55 is critical for stabilization of the mitochondrial proteome. The cleavage by Icp55 stabilizes the substrate proteins by removing destabilizing amino acids | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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