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Literature summary for 3.4.11.18 extracted from
- Expression and biochemical characterization of a type I methionine aminopeptidase of Plasmodium vivax (2015), Protein Expr. Purif., 108, 48-53.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Plasmodium vivax |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | 1 mM, about 10% residual activity. The aminopeptidase activity of the EDTA-inactivated enzyme is successfully restored by Mn2+ | Plasmodium vivax |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | best activator, maximum activity at 1 mM, decrease above | Plasmodium vivax | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52100 | - |
x * 52100, calculated, x * 53000, SDS-PAGE | Plasmodium vivax |
| 53000 | - |
x * 52100, calculated, x * 53000, SDS-PAGE | Plasmodium vivax |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium vivax | A5K7H9 | - |
- |
| Plasmodium vivax Salvador I | A5K7H9 | - |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 436 | - |
pH 7.5, 25°C | Plasmodium vivax |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-methionine 4-methylcoumaryl-7-amide + H2O | - |
Plasmodium vivax | L-methionine + 7-amino-4-methylcoumarin | - |
? | |
| L-methionine 4-methylcoumaryl-7-amide + H2O | - |
Plasmodium vivax Salvador I | L-methionine + 7-amino-4-methylcoumarin | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 52100, calculated, x * 53000, SDS-PAGE | Plasmodium vivax |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PVX_094985 | - |
Plasmodium vivax |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
unstable above | Plasmodium vivax |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Plasmodium vivax |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | - |
Plasmodium vivax |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Plasmodium vivax | calculated | - |
7.4 |
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