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Literature summary for 3.4.11.18 extracted from

  • Xiao, Q.; Zhang, F.; Nacev, B.A.; Liu, J.O.; Pei, D.
    Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases (2010), Biochemistry, 49, 5588-5599.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
IV-43
-
Homo sapiens
TNP-470
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
from an overproducing strain Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
MAEIEIY + H2O
-
Escherichia coli L-Met + AEIEIY
-
?
MAEIEIY + H2O
-
Homo sapiens L-Met + AEIEIY
-
?
MAEWEIY + H2O
-
Homo sapiens L-Met + AEWEIY
-
?
MAGAIHY + H2O
-
Homo sapiens L-Met + AGAIHY
-
?
MAGIEIY + H2O
-
Escherichia coli L-Met + AGIEIY
-
?
MAHAIHY + H2O
-
Homo sapiens L-Met + AHAIHY
-
?
MAHIEIY + H2O
-
Escherichia coli L-Met + AHIEIY
-
?
MAHIEIY + H2O
-
Homo sapiens L-Met + AHIEIY
-
?
MAPIEIY + H2O
-
Homo sapiens L-Met + APIEIY
-
?
MARIEIY + H2O
-
Escherichia coli L-Met + ARIEIY
-
?
MARIEIY + H2O
-
Homo sapiens L-Met + ARIEIY
-
?
MAWIEIY + H2O
-
Homo sapiens L-Met + AWIEIY
-
?
MGEIEIY + H2O
-
Escherichia coli L-Met + GEIEIY
-
?
MGEIEIY + H2O
-
Homo sapiens L-Met + GEIEIY
-
?
additional information substrate specificity is systematically profiled by screening against a combinatorial peptide library and kinetic analysis of individually synthesized peptide substrates Escherichia coli ?
-
?
additional information substrate specificity is systematically profiled by screening against a combinatorial peptide library and kinetic analysis of individually synthesized peptide substrates Homo sapiens ?
-
?
MPEIEIY + H2O
-
Escherichia coli L-Met + PEIEIY
-
?
MPEIEIY + H2O
-
Homo sapiens L-Met + PEIEIY
-
?
MSDFIGY + H2O
-
Escherichia coli L-Met + SDFIGY
-
?
MTEIEIY + H2O
-
Escherichia coli L-Met + TEIEIY
-
?
MTEIEIY + H2O
-
Homo sapiens L-Met + TEIEIY
-
?
MVAAAAY + H2O
-
Homo sapiens L-Met + VAAAAY
-
?
MVEIEIY + H2O
-
Escherichia coli L-Met + VEIEIY
-
?
MVEIEIY + H2O
-
Homo sapiens L-Met + VEIEIY
-
?
MVGVKPY + H2O
-
Homo sapiens L-Met + VGVKPY
-
?
MVHQVLY + H2O
-
Homo sapiens L-Met + VHQVLY
-
?
MVKIEIY + H2O
-
Homo sapiens L-Met + VKIEIY
-
?
MVLSPAY + H2O
-
Homo sapiens L-Met + VLSPAY
-
?
MVNPTVY + H2O
-
Homo sapiens L-Met + VNPTVY
-
?

Synonyms

Synonyms Comment Organism
methionine aminopeptidase 1
-
Escherichia coli
methionine aminopeptidase 1
-
Homo sapiens
methionine aminopeptidase 2
-
Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.007
-
MVKIEIY pH 7.4, temperature not specified in the publication Homo sapiens
0.013
-
MVNPTVY pH 7.4, temperature not specified in the publication Homo sapiens
0.015
-
MVLSPAY pH 7.4, temperature not specified in the publication Homo sapiens
0.028
-
MVGVKPY pH 7.4, temperature not specified in the publication Homo sapiens
0.029
-
MTEIEIY pH 7.4, temperature not specified in the publication Homo sapiens
0.064
-
MVHQVLY pH 7.4, temperature not specified in the publication Homo sapiens
0.13
-
MVAAAAY pH 7.4, temperature not specified in the publication Homo sapiens
0.16
-
MPEIEIY pH 7.4, temperature not specified in the publication Homo sapiens
0.18
-
MGEIEIY pH 7.4, temperature not specified in the publication Homo sapiens
0.38
-
MVEIEIY pH 7.4, temperature not specified in the publication Escherichia coli
1.3
-
MAPIEIY pH 7.4, temperature not specified in the publication Homo sapiens
1.5
-
MTEIEIY pH 7.4, temperature not specified in the publication Escherichia coli
1.7
-
MAEIEIY pH 7.4, temperature not specified in the publication Homo sapiens
3
-
MPEIEIY pH 7.4, temperature not specified in the publication Escherichia coli
3.58
-
MAHIEIY pH 7.4, temperature not specified in the publication Homo sapiens
4.1
-
MGEIEIY pH 7.4, temperature not specified in the publication Escherichia coli
5.3
-
MAEWEIY pH 7.4, temperature not specified in the publication Homo sapiens
6.6
-
MARIEIY pH 7.4, temperature not specified in the publication Homo sapiens
9.6
-
MAWIEIY pH 7.4, temperature not specified in the publication Homo sapiens
10
-
MAGAIHY pH 7.4, temperature not specified in the publication Homo sapiens
13.5
-
MAGIEIY pH 7.4, temperature not specified in the publication Escherichia coli
14
-
MAEIEIY pH 7.4, temperature not specified in the publication Escherichia coli
14.5
-
MAHIEIY pH 7.4, temperature not specified in the publication Escherichia coli
18.9
-
MARIEIY pH 7.4, temperature not specified in the publication Escherichia coli
28
-
MSDFIGY pH 7.4, temperature not specified in the publication Escherichia coli
41
-
MAHAIHY pH 7.4, temperature not specified in the publication Homo sapiens