Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.11.18 extracted from

  • Selvakumar, P.; Lakshmikuttyamma, A.; Das, U.; Pati, H.N.; Dimmock, J.R.; Sharma, R.K.
    NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells (2009), Mol. Cancer, 8, 65.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
adenoviral transfer of c-Myc increaseds the expression of MetAP2 in human umbilical vein endothelial cells and reveals that cellular proliferation may involve a cross-talk between c-Myc and MetAP2 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-({3-[3,5-bis[4-nitrobenzylidene]-4-oxopiperidin-1-yl]-3-oxopropylsulfanyl) ethanesulfonic acid inhibitor of MetAP2 Homo sapiens
fumagillin inhibitor of MetAP2 Homo sapiens
TNP-470 inhibitor of MetAP2 and anticancer drug Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell MetAP2 is overexpressed in human colon cancer Homo sapiens
-
HT-29 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
MetAP2
-
Homo sapiens
methionine aminopeptidase 2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the 3,5-bis(benzylidene)-4-piperidone derivative 2-(3-[3,5-bis[4-nitrobenzylidene]-4-oxopiperidin-1-yl]-3-oxopropylsulfanyl) ethanesulfonic acid, or NC2213, downregulates the enzyme in HT-29 cells down

General Information

General Information Comment Organism
physiological function MetAP2 is a bifunctional protein that plays a critical role in the regulation of post-translational processing and protein synthesis Homo sapiens