Cloned (Comment) | Organism |
---|---|
adenoviral transfer of c-Myc increaseds the expression of MetAP2 in human umbilical vein endothelial cells and reveals that cellular proliferation may involve a cross-talk between c-Myc and MetAP2 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-({3-[3,5-bis[4-nitrobenzylidene]-4-oxopiperidin-1-yl]-3-oxopropylsulfanyl) ethanesulfonic acid | inhibitor of MetAP2 | Homo sapiens | |
fumagillin | inhibitor of MetAP2 | Homo sapiens | |
TNP-470 | inhibitor of MetAP2 and anticancer drug | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | MetAP2 is overexpressed in human colon cancer | Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
MetAP2 | - |
Homo sapiens |
methionine aminopeptidase 2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the 3,5-bis(benzylidene)-4-piperidone derivative 2-(3-[3,5-bis[4-nitrobenzylidene]-4-oxopiperidin-1-yl]-3-oxopropylsulfanyl) ethanesulfonic acid, or NC2213, downregulates the enzyme in HT-29 cells | down |
General Information | Comment | Organism |
---|---|---|
physiological function | MetAP2 is a bifunctional protein that plays a critical role in the regulation of post-translational processing and protein synthesis | Homo sapiens |