Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli strain BL21, Saccharomyces cerevisiae strain INVSc1, and insect cells, none of the recombinant forms of MetAP2 exhibits enzymatic activity | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fumagillin | - |
Plasmodium falciparum | |
fumarranol | - |
Plasmodium falciparum | |
TNP-470 | - |
Plasmodium falciparum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
72000 | - |
MetAP2 overexpressed in Escherichia coli has an apparent molecular weight of 72000Da | Plasmodium falciparum |
90000 | - |
MetAP2 overexpressed in Saccharomyces cerevisiae is approximately 90000 Da | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Met-L-Pro-p-nitroanilide + H2O | - |
Plasmodium falciparum | L-Met + L-Pro-p-nitroanilide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MetAP2 | - |
Plasmodium falciparum |
methionine aminopeptidase 2 | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.002 | - |
in 20 mM Tris-HCl (pH 7.1) and 100 mM KCl, at 37°C | Plasmodium falciparum | fumarranol | |
0.116 | - |
in 20 mM Tris-HCl (pH 7.1) and 100 mM KCl, at 37°C | Plasmodium falciparum | TNP-470 |