Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(1-benzyl-1H-1,2,3-triazol-4-yl)benzene-1,2-diol | does only inhibit Fe2+-activated MetAP enzyme, but not Mn2+- or Co2+-activated MetAP enzymes | Escherichia coli | |
4-(1-methyl-1H-imidazol-2-yl)benzene-1,2-diol | does only inhibit Fe2+-activated MetAP enzyme, but not Mn2+- or Co2+-activated MetAP enzymes | Escherichia coli | |
4-(5-fluoropyrimidin-2-yl)benzene-1,2-diol | does only inhibit Fe2+- or Co2+-activated MetAP enzymes, but not Mn2+-activated MetAP enzyme | Escherichia coli | |
4-(5-methoxy-1,3-oxazol-2-yl)benzene-1,2-diol | does only inhibit Fe2+-activated MetAP enzyme, but not Mn2+- or Co2+-activated MetAP enzymes | Escherichia coli | |
4-pyridin-2-ylbenzene-1,2-diol | does only inhibit Fe2+-activated MetAP enzyme, but not Mn2+- or Co2+-activated MetAP enzymes | Escherichia coli | |
4-pyrimidin-2-ylbenzene-1,2-diol | does only inhibit Fe2+-activated MetAP enzyme, but not Mn2+- or Co2+-activated MetAP enzymes | Escherichia coli | |
ethyl 5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxylate | does only inhibit Fe2+-activated MetAP enzyme, but not Mn2+- or Co2+-activated MetAP enzymes | Escherichia coli | |
N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxamide | does only inhibit Fe2+-activated MetAP enzyme, but not Mn2+- or Co2+-activated MetAP enzymes | Escherichia coli | |
N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | - |
Escherichia coli | |
N-cyclobutyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | - |
Escherichia coli | |
N-cyclopentyl-5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxamide | does only inhibit Fe2+-activated MetAP enzyme, but not Mn2+- or Co2+-activated MetAP enzymes | Escherichia coli | |
N-cyclopentyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | - |
Escherichia coli | |
N-cyclopropyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | does only inhibit Fe2+-activated MetAP enzyme, but not Mn2+- or Co2+-activated MetAP enzymes | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | MetAP requires a divalent metal ion for activation, such as Co2+ | Escherichia coli | |
Fe2+ | MetAP requires a divalent metal ion for activation, such as Fe2+ | Escherichia coli | |
Mn2+ | MetAP requires a divalent metal ion for activation, such as Mn2+ | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Met-peptide + H2O | - |
Escherichia coli | L-Met + peptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MetAP | - |
Escherichia coli |
methionine aminopeptidase | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0009 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | N-cyclopentyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | |
0.001 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | |
0.0012 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | N-cyclobutyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | |
0.0067 | - |
using Mn2+-activated MetAP enzyme | Escherichia coli | N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | |
0.0079 | - |
using Mn2+-activated MetAP enzyme | Escherichia coli | N-cyclobutyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | |
0.0106 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | 4-(5-fluoropyrimidin-2-yl)benzene-1,2-diol | |
0.011 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | N-cyclopentyl-5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxamide | |
0.0112 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | 4-(5-methoxy-1,3-oxazol-2-yl)benzene-1,2-diol | |
0.0118 | - |
using Mn2+-activated MetAP enzyme | Escherichia coli | N-cyclopentyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | |
0.0134 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxamide | |
0.014 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | ethyl 5-(3,4-dihydroxyphenyl)-1,3-oxazole-4-carboxylate | |
0.0148 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | N-cyclopropyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | |
0.0161 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | 4-(1-benzyl-1H-1,2,3-triazol-4-yl)benzene-1,2-diol | |
0.0193 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | 4-pyridin-2-ylbenzene-1,2-diol | |
0.0195 | - |
using Co2+-activated MetAP enzyme | Escherichia coli | 4-(1-benzyl-1H-1,2,3-triazol-4-yl)benzene-1,2-diol | |
0.0212 | - |
using Co2+-activated MetAP enzyme | Escherichia coli | N-but-3-en-1-yl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | |
0.0225 | - |
using Co2+-activated MetAP enzyme | Escherichia coli | N-cyclobutyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | |
0.0246 | - |
using Mn2+-activated MetAP enzyme | Escherichia coli | 4-(1-benzyl-1H-1,2,3-triazol-4-yl)benzene-1,2-diol | |
0.0255 | - |
using Fe2+-activated MetAP enzyme | Escherichia coli | 4-pyrimidin-2-ylbenzene-1,2-diol | |
0.0301 | - |
using Co2+-activated MetAP enzyme | Escherichia coli | N-cyclopentyl-5-(3,4-dihydroxyphenyl)furan-2-carboxamide | |
0.0526 | - |
using Co2+-activated MetAP enzyme | Escherichia coli | 4-(5-fluoropyrimidin-2-yl)benzene-1,2-diol | |
0.1 | - |
IC50 above 0.1 mM, using Fe2+, Co2+, or Mn2+-activated MetAP enzymes | Escherichia coli | 4-(1-methyl-1H-imidazol-2-yl)benzene-1,2-diol |