Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.11.18 extracted from

  • Huang, M.; Xie, S.X.; Ma, Z.Q.; Hanzlik, R.P.; Ye, Q.Z.
    Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides (2006), Biochem. Biophys. Res. Commun., 339, 506-513.
    View publication on PubMed
Search for more literature for 3.4.11.18

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion method with 13-18% PEG 20000, 0.1M Mes (pH 6.5), and 2 mM MnCl2 or 1.2 mM CoCl2 Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
N-(5-chloroquinolin-8-yl)benzenesulfonamide Co(II)-form of enzyme, 50% inhibition at 0.00169 mM, Mn(II)-form, 50% inhibition at 0.0185 mM, Fe(II)-form, at 0.0138 mM, Ni(II)-form, at 0.00742 mM, Zn(II)-form, at 0.0113 mM Escherichia coli
N-(5-chloroquinolin-8-yl)methanesulfonamide Co(II)-form of enzyme, 50% inhibition at 0.000154 mM, Mn(II)-form, 50% inhibition at 0.00164 mM, Fe(II)-form, at 0.00393 mM, Ni(II)-form, at 0.000171 mM, Zn(II)-form, at 0.000806 mM; inhibits the Co(II)- and Ni(II)-forms of MetAP potently Escherichia coli
N-(quinolin-8-yl)methanesulfonamide inhibits the Co(II)- and Ni(II)-forms of MetAP potently Escherichia coli
N-quinolin-8-ylmethanesulfonamide Co(II)-form of enzyme, 50% inhibition at 0.000137 mM, Mn(II)-form, 50% inhibition at 0.00214 mM, Fe(II)-form, at 0.00374 mM, Ni(II)-form, at 0.000184 mM, Zn(II)-form, at 0.00111 mM Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P0AE18
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Met-7-amido-4-methylcoumarin + H2O
-
 Escherichia coli Met + 7-amino-4-methylcoumarin
-
 ?
Met-[2-mercapto-ethanoyl]-Phe + H2O
-
 Escherichia coli [2-mercapto-ethanoyl]-Phe + Met
-
 ?

Synonyms

Synonyms Comment Organism
MetAP
-
 Escherichia coli
methionine aminopeptidase
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000287
-
 N-(5-chloroquinolin-8-yl)methanesulfonamide Co(II)-form of enzyme Escherichia coli
0.0000343
-
 N-quinolin-8-ylmethanesulfonamide Co(II)-form of enzyme Escherichia coli
0.0287
-
 N-(5-chloroquinolin-8-yl)methanesulfonamide
-
 Escherichia coli
0.0343
-
 N-(quinolin-8-yl)methanesulfonamide
-
 Escherichia coli