Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.11.18 extracted from

  • Vetro, J.A.; Chang, Y.H.
    Yeast methionine aminopeptidase type 1 is ribosome-associated and requires its N-terminal zinc finger domain for normal function in vivo (2002), J. Cell. Biochem., 85, 678-688.
    View publication on PubMed
Search for more literature for 3.4.11.18

Protein Variants

Protein Variants Comment Organism
C22S zinc finger point mutant, processing efficiency of the mutant enzyme is less than that of the wild-type enzyme in vivo. Association of the mutant enzyme with the 60S ribosome subunit is disrupted Saccharomyces cerevisiae
DELTA2-69 zinc-finger deletion mutant, processing efficiency of the mutant enzyme is less than that of the wild-type enzyme in vivo Saccharomyces cerevisiae
H62R zinc finger point mutant, processing efficiency of the mutant enzyme is less than that of the wild-type enzyme in vivo. Association of the mutant enzyme with the 60S ribosome subunit is disrupted Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome methionine aminopeptidase type 1 associates primarily with the 60S ribosome subunit, lower affinity or non-specific interaction with the 40S ribosome subunit Saccharomyces cerevisiae 5840
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc methionine aminopeptidase type 1 requires its N-terminal zinc finger domain for normal function in vivo Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione-S-transferase + H2O Saccharomyces cerevisiae removal of Met(init) from glutathione-S-transferase. Processing of glutathione-S-transferase in yeast relies almost entirely on MetAP1 function ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 methionine aminopeptidase 1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione-S-transferase + H2O
-
 Saccharomyces cerevisiae ?
-
 ?
glutathione-S-transferase + H2O removal of Met(init) from glutathione-S-transferase. Processing of glutathione-S-transferase in yeast relies almost entirely on MetAP1 function Saccharomyces cerevisiae ?
-
 ?