Literature summary for 3.4.11.14 extracted from

Garner, C.W.; Behal, F.J.
Effect of pH on substrate and inhibitor kinetic constants of human liver alanine aminopeptidase. Evidence for two ionizable active center groups (1975), Biochemistry, 14, 5084-5088.

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Inhibitors

Inhibitors	Comment	Organism	Structure
D-Leu-Tyr	-	Homo sapiens
Leu-Leu-Leu	-	Homo sapiens
additional information	there are two active centre ionizable groups with pKa values of approximately 6.0 and 7.5 which are involved in substrate binding or inhibitory amino acid binding	Homo sapiens
octanoic acid	competitive	Homo sapiens
octylamine	competitive	Homo sapiens
Phe	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ala-4-nitroanilide + H2O	-	Homo sapiens	?	-	?
additional information	there are two active centre ionizable groups with pKa values of approximately 6.0 and 7.5 which are involved in substrate binding or inhibitory amino acid binding	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)