Literature summary for 3.4.11.10 extracted from

Albrecht, S.; Al-Lakkis-Wehbe, M.; Orsini, A.; Defoin, A.; Pale, P.; Salomon, E.; Tarnus, C.; Weibel, J.
Amino-benzosuberone: A novel warhead for selective inhibition of human aminopeptidase-N/CD13 (2011), Bioorg. Med. Chem., 19, 1434-1449.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-aminoindan-2-one	-	Vibrio proteolyticus
2-aminocycloheptanone	-	Vibrio proteolyticus
3-amino-3,4-dihydro-1H-naphtalen-2-one	-	Vibrio proteolyticus
7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one	-	Vibrio proteolyticus
7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-oxime	-	Vibrio proteolyticus
bestatin	-	Vibrio proteolyticus

Organism

Organism	UniProt	Comment	Textmining
Vibrio proteolyticus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-leucine-4-nitroanilide + H2O	-	Vibrio proteolyticus	L-leucine + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
Aeromonas proteolytica aminopeptidase	-	Vibrio proteolyticus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000016	-	pH 7.5, 25°C	Vibrio proteolyticus	bestatin
0.015	-	pH 7.5, 25°C	Vibrio proteolyticus	7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-oxime
0.13	-	pH 7.5, 25°C	Vibrio proteolyticus	3-amino-3,4-dihydro-1H-naphtalen-2-one
0.15	-	pH 7.5, 25°C	Vibrio proteolyticus	1-aminoindan-2-one
0.35	-	pH 7.5, 25°C	Vibrio proteolyticus	2-aminocycloheptanone
0.9	-	pH 7.5, 25°C	Vibrio proteolyticus	7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one

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Release 2023.1 (January 2023)