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Literature summary for 3.4.11.10 extracted from

  • Albrecht, S.; Defoin, A.; Salomon, E.; Tarnus, C.; Wetterholm, A.; Haeggstroem, J.Z.
    Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors (2006), Bioorg. Med. Chem., 14, 7241-7257.
    View publication on PubMed
Search for more literature for 3.4.11.10

Inhibitors

Inhibitors Comment Organism Structure
2-amino-1,4-dihydro-2-isoquinolin-3-one
-
 Vibrio proteolyticus
2-hydroxy-1,4-dihydro-2H-isoquinolin-3-one
-
 Vibrio proteolyticus
3-amino-1,2,3,4-tetrahydronaphthalene-2-carbohydroxamic acid
-
 Vibrio proteolyticus
3-amino-1,2,3,4-tetrahydronaphthalene-2-ethanone
-
 Vibrio proteolyticus
3-amino-1,2,3,4-tetrahydronaphthalene-2-phosphonic acid
-
 Vibrio proteolyticus
3-amino-2-tetralone
-
 Vibrio proteolyticus
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(2-phenylethyl)oxime
-
 Vibrio proteolyticus
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(3-phenylpropyl)oxime
-
 Vibrio proteolyticus
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(4-phenylbutyl)oxime
-
 Vibrio proteolyticus
3-amino-3,4-dihydro-1H-naphthalen-2-one O-(5-phenylpentyl)oxime
-
 Vibrio proteolyticus
3-amino-3,4-dihydro-1H-naphthalen-2-one O-benzyloxime
-
 Vibrio proteolyticus
3-amino-3,4-dihydro-1H-naphthalen-2-one O-methyloxime
-
 Vibrio proteolyticus
aminoquinolinone
-
 Vibrio proteolyticus
bestatin
-
 Vibrio proteolyticus
isothiochroman-3-one
-
 Vibrio proteolyticus

Organism

Organism UniProt Comment Textmining
Vibrio proteolyticus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-leucine-p-nitroanilide + H2O
-
 Vibrio proteolyticus L-Leu + p-nitroaniline
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.004
-
 3-amino-1,2,3,4-tetrahydronaphthalene-2-carbohydroxamic acid
-
 Vibrio proteolyticus
0.004
-
 isothiochroman-3-one
-
 Vibrio proteolyticus
0.004
-
 2-hydroxy-1,4-dihydro-2H-isoquinolin-3-one
-
 Vibrio proteolyticus
0.08
-
 aminoquinolinone
-
 Vibrio proteolyticus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000016
-
-
 Vibrio proteolyticus bestatin
0.11
-
-
 Vibrio proteolyticus 3-amino-3,4-dihydro-1H-naphthalen-2-one O-(4-phenylbutyl)oxime
0.13
-
-
 Vibrio proteolyticus 3-amino-3,4-dihydro-1H-naphthalen-2-one O-(5-phenylpentyl)oxime
0.13
-
-
 Vibrio proteolyticus 3-amino-2-tetralone
0.15
-
-
 Vibrio proteolyticus 3-amino-1,2,3,4-tetrahydronaphthalene-2-phosphonic acid
0.17
-
-
 Vibrio proteolyticus 3-amino-3,4-dihydro-1H-naphthalen-2-one O-(2-phenylethyl)oxime
0.21
-
-
 Vibrio proteolyticus 3-amino-3,4-dihydro-1H-naphthalen-2-one O-benzyloxime
0.3
-
-
 Vibrio proteolyticus 3-amino-3,4-dihydro-1H-naphthalen-2-one O-(3-phenylpropyl)oxime
0.5
-
-
 Vibrio proteolyticus 3-amino-1,2,3,4-tetrahydronaphthalene-2-ethanone
0.74
-
-
 Vibrio proteolyticus 2-amino-1,4-dihydro-2-isoquinolin-3-one
0.8
-
-
 Vibrio proteolyticus 3-amino-3,4-dihydro-1H-naphthalen-2-one O-methyloxime