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Literature summary for 3.4.11.10 extracted from

  • Jankiewicz, U.; Bielawski, W.
    The properties and functions of bacterial aminopeptidases (2003), Acta Microbiol. Pol., 52, 217-231.
    View publication on PubMed
Search for more literature for 3.4.11.10

Inhibitors

Inhibitors Comment Organism Structure
EDTA complete inactivation, reversible by Zn2+, Co2+, Ni2+, or Cu2+ Vibrio proteolyticus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Pseudomonas aeruginosa
-
-
extracellular
-
 Vibrio proteolyticus
-
-
intracellular
-
 Salmonella enterica subsp. enterica serovar Typhimurium 5622
-
intracellular
-
 Escherichia coli 5622
-
intracellular
-
 Pseudomonas aeruginosa 5622
-
intracellular
-
 Vibrio proteolyticus 5622
-
plasma membrane the enzyme is asscoiated to the internal membrane surface Lactococcus sp. 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metallopeptidase, the kind of bound metal ion determines the substrate specificity Salmonella enterica subsp. enterica serovar Typhimurium
additional information metallopeptidase, the kind of bound metal ion determines the substrate specificity Escherichia coli
additional information metallopeptidase, the kind of bound metal ion determines the substrate specificity Vibrio proteolyticus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 extracellular enzymes show a low MW of 20-30 kDa Pseudomonas aeruginosa
additional information
-
 extracellular enzymes show a low MW of 20-30 kDa Vibrio proteolyticus
18000
-
 12 * 18000 Brevibacterium linens
47000
-
 x * 47000 + x * 50000 Mycoplasma salivarium
50000
-
 8 * 50000, about Pseudomonas putida
50000
-
 x * 47000 + x * 50000 Mycoplasma salivarium
55000
-
 6 * 55000 Escherichia coli
400000
-
-
 Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Salmonella enterica subsp. enterica serovar Typhimurium aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview ?
-
 ?
additional information Escherichia coli aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview ?
-
 ?
additional information Pseudomonas aeruginosa aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview ?
-
 ?
additional information Pseudomonas putida aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview ?
-
 ?
additional information Brevibacterium linens aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview ?
-
 ?
additional information Vibrio proteolyticus aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview ?
-
 ?
additional information Mycoplasma salivarium aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview ?
-
 ?
additional information Lactococcus sp. the enzyme is involved in transport and degradation of extracellular peptides, and are important in uptake of nutrients, regulation, overview ?
-
 ?
additional information Brevibacterium linens SR3 aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Brevibacterium linens
-
-
-
Brevibacterium linens SR3
-
-
-
Escherichia coli
-
-
-
Lactococcus sp.
-
-
-
Mycoplasma salivarium
-
-
-
Pseudomonas aeruginosa
-
-
-
Pseudomonas putida
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Vibrio proteolyticus
-
 formerly Aeromonas proteolytica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
additional information aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview Escherichia coli ?
-
 ?
additional information aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview Pseudomonas aeruginosa ?
-
 ?
additional information aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview Pseudomonas putida ?
-
 ?
additional information aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview Brevibacterium linens ?
-
 ?
additional information aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview Vibrio proteolyticus ?
-
 ?
additional information aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview Mycoplasma salivarium ?
-
 ?
additional information the enzyme is involved in transport and degradation of extracellular peptides, and are important in uptake of nutrients, regulation, overview Lactococcus sp. ?
-
 ?
additional information the enzyme shows broad substrate specificity preferring N-terminal Leu or Met and Phe, but is not able to hydrolyse peptide substrates bonds with formed by acidic amino acids in the P1 position or proline in the P1 or P1' position Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
additional information the enzyme shows broad substrate specificity preferring N-terminal Leu or Met and Phe, but is not able to hydrolyse peptide substrates bonds with formed by acidic amino acids in the P1 position or proline in the P1 or P1' position Escherichia coli ?
-
 ?
additional information the enzyme shows broad substrate specificity preferring N-terminal Leu or Met and Phe, but is not able to hydrolyse peptide substrates bonds with formed by acidic amino acids in the P1 position or proline in the P1 or P1' position Pseudomonas aeruginosa ?
-
 ?
additional information the enzyme shows broad substrate specificity preferring N-terminal Leu or Met and Phe, but is not able to hydrolyse peptide substrates bonds with formed by acidic amino acids in the P1 position or proline in the P1 or P1' position Vibrio proteolyticus ?
-
 ?
additional information aminopeptidases are involved in peptides processing and degradation, and are important in uptake of nutrients, regulation, overview Brevibacterium linens SR3 ?
-
 ?

Subunits

Subunits Comment Organism
? x * 47000 + x * 50000 Mycoplasma salivarium
dodecamer 12 * 18000 Brevibacterium linens
hexamer 6 * 55000 Escherichia coli
octamer 8 * 50000, about Pseudomonas putida

Synonyms

Synonyms Comment Organism
aminopeptidase A
-
 Escherichia coli
aminopeptidase A
-
 Lactococcus sp.
bacterial leucine aminopeptidase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
bacterial leucine aminopeptidase
-
 Escherichia coli
bacterial leucine aminopeptidase
-
 Pseudomonas aeruginosa
bacterial leucine aminopeptidase
-
 Pseudomonas putida
bacterial leucine aminopeptidase
-
 Brevibacterium linens
bacterial leucine aminopeptidase
-
 Vibrio proteolyticus
PepA
-
 Escherichia coli