Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Escherichia coli | P77455 | - |
- |
Synonyms | Comment | Organism |
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paaZ | - |
Escherichia coli |
General Information | Comment | Organism |
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malfunction | Eschericha coli K12 mutants with a deletion of the paaZ gene are unable to grow with phenylacetate as carbon source. The paaZ mutant converts phenylacetate into ortho-hydroxyphenylacetate | Escherichia coli |
physiological function | mutants with a deletion of the paaF, paaG, paaH, paaJ or paaZ gene are unable to grow with phenylacetate as carbon source. The paaG and paaZ mutants convert phenylacetate into ortho-hydroxyphenylacetate. Results suggest a catabolic pathway via CoA thioesters. Phenylacetyl-CoA is attacked by a ring-oxygenase/reductase, PaaABCDE proteins, generating a hydroxylated and reduced derivative of phenylacetyl-CoA, which is not re-oxidized to a dihydroxylated aromatic intermediate but is further metabolized in a complex reaction sequence comprising enoyl-CoA isomerization/hydration, nonoxygenolytic ring opening, and dehydrogenation catalyzed by the PaaG and PaaZ proteins. The subsequent beta-oxidation-type degradation of the resulting CoA dicarboxylate via beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA appears to be catalyzed by the PaaJ, PaaF and PaaH proteins | Escherichia coli |