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Literature summary for 3.2.2.9 extracted from

  • Wang, S.; Lim, J.; Thomas, K.; Yan, F.; Angeletti, R.H.; Schramm, V.L.
    A complex of methylthioadenosine/S-adenosylhomocysteine nucleosidase, transition state analogue, and nucleophilic water identified by mass spectrometry (2012), J. Am. Chem. Soc., 134, 1468-1470.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(3R,4S)-4-(1-butylthiomethyl)-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine
-
Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26030
-
2 * 26030, calculated from amino acid sequence and acquired by nanoESI-QTOF mass spectrometry Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-homocysteine + H2O Escherichia coli
-
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-homocysteine + H2O
-
Escherichia coli S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 26030, calculated from amino acid sequence and acquired by nanoESI-QTOF mass spectrometry Escherichia coli

Synonyms

Synonyms Comment Organism
methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
Escherichia coli
MTAN
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000000003
-
(3R,4S)-4-(1-butylthiomethyl)-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine pH and temperature not specified in the publication Escherichia coli