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Literature summary for 3.2.2.9 extracted from

  • Bao, Y.; Li, Y.; Jiang, Q.; Zhao, L.; Xue, T.; Hu, B.; Sun, B.
    Methylthioadenosine/S-adenosylhomocysteine nucleosidase (Pfs) of Staphylococcus aureus is essential for the virulence independent of LuxS/AI-2 system (2013), Int. J. Med. Microbiol., 303, 190-200.
    View publication on PubMed
Search for more literature for 3.2.2.9

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DH5alpha cells Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-homocysteine + H2O Staphylococcus aureus
-
 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
S-adenosyl-L-homocysteine + H2O Staphylococcus aureus NCTC 8325
-
 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
S-adenosyl-L-homocysteine + H2O Staphylococcus aureus RN4220
-
 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus NCTC 8325
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus NCTC 8325 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
S-adenosyl-L-homocysteine + H2O
-
 Staphylococcus aureus RN4220 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?

Synonyms

Synonyms Comment Organism
methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
 Staphylococcus aureus
MTA/SAH nucleosidase
-
 Staphylococcus aureus
Pfs
-
 Staphylococcus aureus

General Information

General Information Comment Organism
physiological function the enzyme is essential for the virulence of Staphylococcus aureus and contributes to sepsis infection of mice. The enzyme is not essential for growth under nutrient-rich conditions, but is essential for autoinducer-2 production Staphylococcus aureus