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Literature summary for 3.2.2.9 extracted from

  • Parveen, N.; Cornell, K.A.
    Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism (2011), Mol. Microbiol., 79, 7-20.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine inhibitors of methylthioadenosine/S-adenosylhomocysteine nucleosidase are anti-infective drugs against various bacterial pathogens Escherichia coli
medicine inhibitors of MTA/SAH nucleosidase are anti-infective drugs against various bacterial pathogens Borreliella burgdorferi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-deoxyadenosine + H2O Escherichia coli
-
5-deoxy-D-ribose + adenine
-
?
5'-deoxyadenosine + H2O Borreliella burgdorferi
-
5-deoxy-D-ribose + adenine
-
?
5'-methylthioadenosine + H2O Escherichia coli
-
5-methylthio-D-ribose + adenine
-
?
5'-methylthioadenosine + H2O Borreliella burgdorferi
-
5-methylthio-D-ribose + adenine
-
?
S-adenosyl-L-homocysteine + H2O Escherichia coli
-
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
?
S-adenosyl-L-homocysteine + H2O Borreliella burgdorferi
-
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
?

Organism

Organism UniProt Comment Textmining
Borreliella burgdorferi
-
-
-
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-deoxyadenosine + H2O
-
Escherichia coli 5-deoxy-D-ribose + adenine
-
?
5'-deoxyadenosine + H2O
-
Borreliella burgdorferi 5-deoxy-D-ribose + adenine
-
?
5'-methylthioadenosine + H2O
-
Escherichia coli 5-methylthio-D-ribose + adenine
-
?
5'-methylthioadenosine + H2O
-
Borreliella burgdorferi 5-methylthio-D-ribose + adenine
-
?
S-adenosyl-L-homocysteine + H2O
-
Escherichia coli S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
?
S-adenosyl-L-homocysteine + H2O
-
Borreliella burgdorferi S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
?

Subunits

Subunits Comment Organism
dimer
-
Escherichia coli
dimer
-
Borreliella burgdorferi

Synonyms

Synonyms Comment Organism
Bgp
-
Borreliella burgdorferi
methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
Escherichia coli
methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
Borreliella burgdorferi
MTA/SAH nucleosidase
-
Escherichia coli
MTA/SAH nucleosidase
-
Borreliella burgdorferi
Pfs
-
Escherichia coli
Pfs
-
Borreliella burgdorferi

General Information

General Information Comment Organism
physiological function the enzyme is involved in the synthesis of 4,5-dihdroxy-2,3-pentanedione from methionine. S-adenosyl-L-homocysteine hydrolysis by MTA/SAH nucleosidase yields S-(5-deoxy-D-ribos-5-yl)-L-homocysteine, a precursor of autoinducer-2 synthesis, a quorum-sensing signal that governs a variety of bacterial phenotypes such as virulence and biofilm formation Escherichia coli
physiological function the enzyme is involved in the synthesis of 4,5-dihdroxy-2,3-pentanedione from methionine. S-adenosyl-L-homocysteine hydrolysis by MTA/SAH nucleosidase yields S-(5-deoxy-D-ribos-5-yl)-L-homocysteine, a precursor of autoinducer-2 synthesis, a quorum-sensing signal that governs a variety of bacterial phenotypes such as virulence and biofilm formation Borreliella burgdorferi