Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+/-)-cis-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine | - |
Escherichia coli | |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(1H-1,2,3-triazol-4-yl)pyrrolidine | - |
Escherichia coli | |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(penta-3-yl)pyrrolidine | - |
Escherichia coli | |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-isobutylpyrrolidine | - |
Escherichia coli | |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-phenylpyrrolidine | - |
Escherichia coli | |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-vinylpyrrolidine | - |
Escherichia coli | |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-4-ethynyl-3-hydroxypyrrolidine | - |
Escherichia coli | |
(+/-)-trans-4-(1-benzyl-1H-1,2,3-triazol-4-yl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | - |
Escherichia coli | |
(+/-)-trans-4-(cyclohexylmethyl)-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine | - |
Escherichia coli | |
(+/-)-trans-4-allyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | - |
Escherichia coli | |
(+/-)-trans-4-butyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | - |
Escherichia coli | |
(+/-)-trans-4-cyclopentyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | - |
Escherichia coli | |
(+/-)-trans-4-cyclopropyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | - |
Escherichia coli | |
(+/-)-trans-4-[3-(benzylthio)propyl]-1-[(9-deazaadenin-9-yl)-methyl]-3-hydroxypyrrolidine | - |
Escherichia coli | |
(+/-)trans-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine | - |
Escherichia coli | |
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine | - |
Escherichia coli | |
(3R,4S)-4-butyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | - |
Escherichia coli | |
(3R,4S)-butylthio-5'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin | - |
Escherichia coli | |
(3R,4S)-ethylthio-5'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin | - |
Escherichia coli | |
(3R,4S)-methylthio-5'-deaza-1'-aza-2'-deoxy-1'-(9-methylene)-immucillin | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-methylthioadenosine + H2O | Escherichia coli | - |
5-methylthio-D-ribose + adenine | - |
? | |
S-adenosyl-L-homocysteine + H2O | Escherichia coli | - |
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-methylthioadenosine + H2O | - |
Escherichia coli | 5-methylthio-D-ribose + adenine | - |
? | |
S-adenosyl-L-homocysteine + H2O | - |
Escherichia coli | S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | dual substrate enzyme | Escherichia coli |
MTAN | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000034 | - |
(3R,4S)-4-butyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.000009 | - |
(+/-)-trans-4-butyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.000013 | - |
(+/-)-trans-4-cyclopentyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.00003 | - |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-phenylpyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.000047 | - |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-isobutylpyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.000054 | - |
(+/-)-trans-4-[3-(benzylthio)propyl]-1-[(9-deazaadenin-9-yl)-methyl]-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.000059 | - |
(+/-)-trans-4-(cyclohexylmethyl)-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.000063 | - |
(+/-)-trans-4-cyclopropyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.000064 | - |
(+/-)-trans-4-(1-benzyl-1H-1,2,3-triazol-4-yl)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.00031 | - |
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.00035 | - |
(+/-)-trans-4-allyl-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.00039 | - |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-4-ethynyl-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.00065 | - |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-vinylpyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.0007 | - |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(penta-3-yl)pyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.00084 | - |
(+/-)trans-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.0018 | - |
(+/-)-cis-1-[(9-deazaadenin-9-yl)methyl]-4-ethyl-3-hydroxypyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli | |
0.002 | - |
(+/-)-trans-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(1H-1,2,3-triazol-4-yl)pyrrolidine | in 100 mM HEPES, pH 7.4, 50 mM KCl, at 25°C | Escherichia coli |