Literature summary for 3.2.2.9 extracted from

Singh, V.; Lee, J.E.; Nunez, S.; Howell, P.L.; Schramm, V.L.
Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues (2005), Biochemistry, 44, 11647-11659.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	the transition state structure of the enzyme predictes that transition state analogue inhibitors resembling 5'-methylthioadenosine with riboxacarbenium features in the ribosyl group and elevated pKa values in the leaving group adenine analogue would be powerful inhibitors	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5'-methylthioadenosine + H2O	-	Escherichia coli	5-methylthio-D-ribose + adenine	-	?

Synonyms

Synonyms	Comment	Organism
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	-	Escherichia coli
MTAN	-	Escherichia coli

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Release 2023.1 (January 2023)