Literature summary for 3.2.2.6 extracted from

Kellenberger, E.; Kuhn, I.; Schuber, F.; Muller-Steffner, H.
Flavonoids as inhibitors of human CD38 (2011), Bioorg. Med. Chem. Lett., 21, 3939-3942.

Search for more literature for 3.2.2.6

Cloned(Commentary)

Cloned (Comment)	Organism
the soluble ecto-domain of human CD38 is expressed in Pichia pastoris	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromenium	-	Homo sapiens
cyanidin	-	Homo sapiens
delphinidin	-	Homo sapiens
fisetinidin	-	Homo sapiens
kuromanin	-	Homo sapiens
luteolin	-	Homo sapiens
luteolinidin	-	Homo sapiens
malvidin	-	Homo sapiens
additional information	not inhibited by rac-taxifolin, rac-catechin, piceatannol, and trans-resveratrol	Homo sapiens
myricetin	-	Homo sapiens
pelargonidin	-	Homo sapiens
peonidin	-	Homo sapiens
petunidin	-	Homo sapiens
quercetagetin	-	Homo sapiens
quercetagetinidin	-	Homo sapiens
quercetin	-	Homo sapiens
robinetin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1,N6-etheno NAD+ + H2O	-	Homo sapiens	epsilon-ADP-ribose + nicotinamide + H+	-	?
additional information	CD38 is a multifunctional enzyme catalyzing the conversion of NAD(P)+ to three metabolites (cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate and ADP-ribose)	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
CD38	-	Homo sapiens
NAD(P) nucleosidase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.006	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	luteolinidin
0.0063	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	kuromanin
0.0082	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	luteolin
0.0142	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	quercetagetinidin
0.0146	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	delphinidin
0.0163	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	pelargonidin
0.017	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	malvidin
0.0209	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	peonidin
0.0218	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	cyanidin
0.0248	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	myricetin
0.0321	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromenium
0.0379	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	quercetin
0.0379	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	robinetin
0.0392	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	petunidin
0.0486	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	quercetagetin
0.0703	-	at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene	Homo sapiens	fisetinidin

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Release 2023.1 (January 2023)