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Literature summary for 3.2.2.29 extracted from
- Efficient removal of uracil from GNU mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells (1994), Proc. Natl. Acad. Sci. USA, 91, 1642-1646.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
x * 55000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thymine-mismatched double-stranded DNA + H2O | Homo sapiens | - |
thymine + double-stranded DNA with abasic site | - |
? |  |
| uracil-mismatched double-stranded DNA + H2O | Homo sapiens | biological role in vivo may also include the correction of a subset of G/U mispairs inefficiently removed by the more abundant ubiquitous uracil glycosylases | uracil + double-stranded DNA with abasic site | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-bromouracil-mismatched double-stranded DNA + H2O | in addition to uracil and thymine, the protein can also remove 5-bromouracil from mispairs with guanine | Homo sapiens | 5-bromouracil + double-stranded DNA with abasic site | - |
? | |
| thymine-mismatched double-stranded DNA + H2O | - |
Homo sapiens | thymine + double-stranded DNA with abasic site | - |
? | |
| thymine-mismatched double-stranded DNA + H2O | in addition to uracil and thymine, the protein can also remove 5-bromouracil from mispairs with guanine | Homo sapiens | thymine + double-stranded DNA with abasic site | - |
? | |
| uracil-mismatched double-stranded DNA + H2O | biological role in vivo may also include the correction of a subset of G/U mispairs inefficiently removed by the more abundant ubiquitous uracil glycosylases | Homo sapiens | uracil + double-stranded DNA with abasic site | - |
? | |
| uracil-mismatched double-stranded DNA + H2O | in addition to uracil and thymine, the protein can also remove 5-bromouracil from mispairs with guanine | Homo sapiens | uracil + double-stranded DNA with abasic site | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 55000, SDS-PAGE | Homo sapiens |
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