Literature summary for 3.2.2.29 extracted from

Mohan, R.D.; Rao, A.; Gagliardi, J.; Tini, M.
SUMO-1-dependent allosteric regulation of thymine DNA glycosylase alters subnuclear localization and CBP/p300 recruitment (2007), Mol. Cell. Biol., 27, 229-243.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	in untransfected MCF-7 cells, endogenous TDG staining is observed in a granular pattern throughout the nucleoplasm. A subpopulation of cells consistently displays increased staining within the promyelocytic leukemia protein oncogenic domains. SUMO-1 binding activity of TDG may be required for targeting to these nuclear structures	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13569	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	in untransfected MCF-7 cells, endogenous TDG staining is observed in a granular pattern throughout the nucleoplasm. A subpopulation of cells consistently displays increased staining within the promyelocytic leukemia protein oncogenic domains. SUMO-1 binding activity of TDG may be required for targeting to these nuclear structures. Sumoylation of TDG regulates association with CREB-binding protein and subnuclear localization	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
TDG	-	Homo sapiens
thymine DNA glycosylase	-	Homo sapiens

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Release 2023.1 (January 2023)