KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic parameters for the opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | hSMUG1 shows excision activity for 5-formyluracil, a major thymine lesion formed by ionizing radiation, opposite all normal bases in DNA | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fU-containing 10 nucleotide DNA sequence 5'-GGAGAfUCTCC-3' with opposing C, T, A, or G + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | hSMUG1 shows excision activity for 5-formyluracil, a major thymine lesion formed by ionizing radiation, opposite all normal bases in DNA | Homo sapiens | ? | - |
? | |
additional information | excision of 5-formyluracil, fU, from fU-containing 10 nucleotide DNA sequence 5'-GGAGAfUCTCC-3'. Substrate-binding pocket of hSMUG1 and its interactions with uracil and fU, base-pairing properties of fU residues in DNA, structures, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | homology modelling of the structure of hSMUG1 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
single-strand-selective monofunctional uracil-DNA glycosylase | - |
Homo sapiens |
SMUG1 | - |
Homo sapiens |
UNG2 | - |
Homo sapiens |
uracil-N-glycosylase 2 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | 0.0003 | fU-containing 10 nucleotide DNA sequence 5'-GGAGAfUCTCC-3' with opposing C, T, A, or G | pH 7.5 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |