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Literature summary for 3.2.2.22 extracted from
- Depletion of sphingolipids facilitates endosome to Golgi transport of ricin (2006), Traffic, 7, 1243-1253.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | study on the endosome to Golgi transport of ricin in cell line LY-B deficient in serine palmitoyltransferase and in wildtype CHO-K1 cells in presence/absence of the inhibitor of sphingolipid biosynthesis, myriocin. Depletion of sphingolipids results in increased sensitivity to ricin. Endosome to Golgi transport of ricin is increased in sphingolipid-deficient cells. Additionally, cholesterol depletion inhibits endosome to Golgi transport even in cells with reduced levels of sphingolipids | Ricinus communis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ricinus communis | - |
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Release 2023.1 (January 2023)
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