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Literature summary for 3.2.2.22 extracted from

  • Sha, O.; Kwong, W.H.; Pang Cho, E.Y.; Wai Yew, D.T.; Ng, T.B.
    Different neuronal toxicity of single-chain ribosome-inactivating proteins on the rat retina (2008), Toxicon, 51, 45-53.
    View publication on PubMed

Application

Application Comment Organism
medicine injection of ricin A chain or of Ricinus communis agglutinin into rat eyes at 0.01 nM bring about acute retinal inflammation and necrosis Ricinus communis
medicine injection of trichosanthin into rat eyes causes distinct retinal changes at 1 nM. Toxic effects are most pronounced in the cells of the outer nuclear layer, less pronounced on those of the inner nuclear layer, and little on the ganglion cells. Apoptosis is the predominant type of cell death induced by trichosanthin Trichosanthes kirilowii

Organism

Organism UniProt Comment Textmining
Ricinus communis
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Trichosanthes kirilowii
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Source Tissue

Source Tissue Comment Organism Textmining