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Literature summary for 3.2.2.22 extracted from

  • Korennykh, A.V.; Correll, C.C.; Piccirilli, J.A.
    Evidence for the importance of electrostatics in the function of two distinct families of ribosome inactivating toxins (2007), RNA, 13, 1391-1396.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.22

Activating Compound

Activating Compound Comment Organism Structure
additional information depurination shows strong salt sensitivity, mechanism of electrostatically facilitatetd ribosome targeting Ricinus communis
additional information depurination shows strong salt sensitivity, mechanism of electrostatically facilitatetd ribosome targeting Saponaria officinalis

Inhibitors

Inhibitors Comment Organism Structure
additional information depurination shows strong salt sensitivity, mechanism of electrostatically facilitatetd ribosome targeting Ricinus communis
additional information depurination shows strong salt sensitivity, mechanism of electrostatically facilitatetd ribosome targeting Saponaria officinalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000055
-
 rRNA 37°C, presence of 50 mM KCl, 1 mM MgCl2 Saponaria officinalis
0.0026
-
 rRNA ricin A chain, 37°C, presence of 50 mM KCl, 1 mM MgCl2 Ricinus communis

Organism

Organism UniProt Comment Textmining
Ricinus communis
-
-
-
Saponaria officinalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
rRNA + H2O source: rat liver ribosome, surface charge properties of enzyme correlate with the presence of the transport chain within the enzyme molecule Ricinus communis ?
-
 ?
rRNA + H2O source: rat liver ribosome, surface charge properties of enzyme correlate with the presence of the transport chain within the enzyme molecule Saponaria officinalis ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
29.6
-
 rRNA ricin A chain, 37°C, presence of 50 mM KCl, 1 mM MgCl2 Ricinus communis
62
-
 rRNA 37°C, presence of 50 mM KCl, 1 mM MgCl2 Saponaria officinalis