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Literature summary for 3.2.2.22 extracted from

  • Slominska-Wojewodzka, M.; Gregers, T.F.; Waelchli, S.; Sandvig, K.
    EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol (2006), Mol. Biol. Cell, 17, 1664-1675.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine ricin interacts with the ER degradation enhancing alpha-mannosidase I-like protein EDEM responsible for redirecting aberrant proteins for ER-associated protein degradation and with Sec61alpha, and both kifunensin and puromycin enhance these interactions. Overexpression of EDEM strongly protects against ricin. In presence of kifunensin, EDEM promotes retranslocation of ricin from the ER to the cytosol Ricinus communis

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Ricinus communis
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Source Tissue

Source Tissue Comment Organism Textmining

Subunits

Subunits Comment Organism
More ricin interacts with the ER degradation enhancing alpha-mannosidase I-like protein EDEM responsible for redirecting aberrant proteins for ER-associated protein degradation and with Sec61alpha, and both kifunensin and puromycin enhance these interactions. Overexpression of EDEM strongly protects against ricin. In presence of kifunensin, EDEM promotes retranslocation of ricin from the ER to the cytosol Ricinus communis