Application | Comment | Organism |
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medicine | ricin interacts with the ER degradation enhancing alpha-mannosidase I-like protein EDEM responsible for redirecting aberrant proteins for ER-associated protein degradation and with Sec61alpha, and both kifunensin and puromycin enhance these interactions. Overexpression of EDEM strongly protects against ricin. In presence of kifunensin, EDEM promotes retranslocation of ricin from the ER to the cytosol | Ricinus communis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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Organism | UniProt | Comment | Textmining |
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Ricinus communis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
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Subunits | Comment | Organism |
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More | ricin interacts with the ER degradation enhancing alpha-mannosidase I-like protein EDEM responsible for redirecting aberrant proteins for ER-associated protein degradation and with Sec61alpha, and both kifunensin and puromycin enhance these interactions. Overexpression of EDEM strongly protects against ricin. In presence of kifunensin, EDEM promotes retranslocation of ricin from the ER to the cytosol | Ricinus communis |