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Literature summary for 3.2.2.22 extracted from

  • Sturm, M.B.; Roday, S.; Schramm, V.L.
    Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design (2007), J. Am. Chem. Soc., 129, 5544-5550.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
CGCG-(N-benzyl-aza-ribosyl)-GAGCG
-
Ricinus communis
cyclic dG-(N-benzyl-aza-deoxyribosyl)-dGd-N-benzyl-aza-deoxyribose
-
Ricinus communis
cyclic dG-(N-benzyl-aza-deoxyribosyl)-dGdA
-
Ricinus communis
cyclic G-(N-benzyl-aza-ribosyl)-GA
-
Ricinus communis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0084
-
dGdCdGdCdGdAdGdAdGdCdGdC pH 4.0, 37°C Ricinus communis
0.038
-
cyclic GdAGA pH 4.0, 37°C Ricinus communis
0.039
-
cyclic dG-(N-benzyl-aza-deoxyribosyl)-dGdA pH 4.0, 37°C Ricinus communis
0.046
-
cyclic phosphorothioyl dGdAdGdA pH 4.0, 37°C Ricinus communis
0.065
-
GdAGA pH 4.0, 37°C Ricinus communis
0.097
-
cyclic dGdAdGdA pH 4.0, 37°C Ricinus communis
0.112
-
dGdAdGdA pH 4.0, 37°C Ricinus communis

Organism

Organism UniProt Comment Textmining
Ricinus communis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic dG-(N-benzyl-aza-deoxyribosyl)-dGdA + H2O
-
Ricinus communis ?
-
?
cyclic dGdAdGdA + H2O
-
Ricinus communis ?
-
?
cyclic GdAGA + H2O
-
Ricinus communis ?
-
?
cyclic phosphorothioyl dGdAdGdA + H2O ring closure via a phosphorothioate bond Ricinus communis ?
-
?
dGdAdGdA + H2O
-
Ricinus communis ?
-
?
dGdCdGdCdGdAdGdAdGdCdGdC + H2O
-
Ricinus communis ?
-
?
GdAGA + H2O
-
Ricinus communis ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.003
-
GdAGA pH 4.0, 37°C Ricinus communis
0.0045
-
dGdAdGdA pH 4.0, 37°C Ricinus communis
0.0083
-
dGdCdGdCdGdAdGdAdGdCdGdC pH 4.0, 37°C Ricinus communis
0.018
-
cyclic dG-(N-benzyl-aza-deoxyribosyl)-dGdA pH 4.0, 37°C Ricinus communis
0.018
-
cyclic GdAGA pH 4.0, 37°C Ricinus communis
0.108
-
cyclic dGdAdGdA pH 4.0, 37°C Ricinus communis
0.15
-
cyclic phosphorothioyl dGdAdGdA pH 4.0, 37°C Ricinus communis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00007
-
cyclic G-(N-benzyl-aza-ribosyl)-GA 37°C, pH 4.0 Ricinus communis
0.000099
-
CGCG-(N-benzyl-aza-ribosyl)-GAGCG 37°C, pH 4.0 Ricinus communis
0.0013
-
cyclic dG-(N-benzyl-aza-deoxyribosyl)-dGd-N-benzyl-aza-deoxyribose 37°C, pH 4.0 Ricinus communis
0.0027
-
cyclic dG-(N-benzyl-aza-deoxyribosyl)-dGdA 37°C, pH 4.0 Ricinus communis